Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3868
Título: Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control study
Autor: Gaio, Vânia
Nunes, Baltazar
Pechirra, Pedro
Conde, Patrícia
Guiomar, Raquel
Dias, Carlos Matias
Barreto, Marta
Palavras-chave: Influenza A(H1N1)pdm09
Gene IFITM3
Respiratory Infections
Hospitalization Risk
Portuguese Influenza Surveillance Program
Public Health
Portugal
Gripe
Infecções Respiratórias
Risco de Hospitalização
Estados de Saúde e de Doença
Data: 28-Jun-2016
Editora: Public Library of Science
Citação: PLoS One. 2016;11(6):e0158181. Epub 2016 Jun 28. doi: 10.1371/journal.pone.0158181.
Resumo: Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza. A case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252. We selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95%CI: 0.33–1.50)). Regarding ILI Influenza A(H1N1)pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95%CI: 1.54–4.19)). The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3868
DOI: 10.1371/journal.pone.0158181
ISSN: 1932-6203
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158181
Aparece nas colecções:DEP - Artigos em revistas internacionais
DDI - Artigos em revistas internacionais

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