Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3816
Título: Relevance of physicochemical characterization in nanotoxicology studies
Autor: Louro, Henriqueta
Tavares, Ana
Pinhão, Mariana
Santos, Joana
Silva, M.J.
Palavras-chave: Genotoxicidade Ambiental
Environmental Genotoxicity
Nanomaterials
Physicochemichal Characterization
Data: 8-Abr-2016
Editora: Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
Resumo: Nanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs. The importance of considering complexity of in vivo systems in nanotoxicology, such as the use of tridimensional cellular models, air-liquid interface exposure or in vivo models that mimic human routes of exposure, is underlined.
Peer review: no
URI: http://hdl.handle.net/10400.18/3816
Aparece nas colecções:DGH - Apresentações orais em encontros internacionais

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