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Title: Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface
Authors: Marques, L.
Auriac, A.
Willemetz, A.
Banha, J.
Silva, B.
Canonne-Hergaux, F.
Costa, L.
Keywords: Determinantes Imunológicos em Doenças Crónicas
Lipid raft
Immune cells
Iron metabolism
Doenças Genéticas
Issue Date: 15-Dec-2011
Publisher: Elsevier
Citation: Blood Cells Mol Dis. 2011 Dec 15. [Epub ahead of print]
Abstract: Ceruloplasmin is a positive acute-phase protein with both anti- and pro-oxidant activities, thus having still unclear physiological functions in inflammatory processes. Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux. Ceruloplasmin can be expressed as a secreted or as a membrane glycosylphosphatidylinositol-anchored protein (GPI-ceruloplasmin), this latter one being reported as expressed mostly in the brain.
Peer review: yes
Publisher Version:
Appears in Collections:DGH - Artigos em revistas internacionais
DPSPDNT - Artigos em revistas internacionais

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