Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3510
Título: Methylotroph Infections and Chronic Granulomatous Disease
Autor: Falcone, E. Liana
Petts, Jennifer
Fasano, Mary Beth
Ford, Bradley
Nauseef, William
Neves, João Farela
Simões, Maria João
Tierce, Millard
Morena, M. Teresa
Greenberg, David
Zerbe, Christa
Zelazny, Adrian
Holland, Steven
Palavras-chave: Cidomonas Methanolica
Granulibacter Bethesdensis
Methylobacterium lusitanum
Chronic Granulomatous Disease
Infecções Respiratórias
Data: Mar-2016
Editora: Centers for Disease Control and Prevention
Citação: Emerg Infect Dis. 2016 Mar;22(3):404-9. doi: 10.3201/eid2203.151265.
Resumo: Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in production of phagocyte-derived reactive oxygen species, which leads to recurrent infections with a characteristic group of pathogens not previously known to include methylotrophs. Methylotrophs are versatile environmental bacteria that can use single-carbon organic compounds as their sole source of energy; they rarely cause disease in immunocompetent persons. We have identified 12 infections with methylotrophs (5 reported here, 7 previously reported) in patients with CGD. Methylotrophs identified were Granulibacter bethesdensis (9 cases), Acidomonas methanolica (2 cases), and Methylobacterium lusitanum (1 case). Two patients in Europe died; the other 10, from North and Central America, recovered after prolonged courses of antimicrobial drug therapy and, for some, surgery. Methylotrophs are emerging as disease-causing organisms in patients with CGD. For all patients, sequencing of the 16S rRNA gene was required for correct diagnosis. Geographic origin of the methylotroph strain may affect clinical management and prognosis.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3510
DOI: 10.3201/eid2203.151265
ISSN: 1080-6040
Versão do Editor: http://wwwnc.cdc.gov/eid/article/22/3/15-1265_article
Aparece nas colecções:DDI - Artigos em revistas internacionais

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