Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3437
Título: Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Autor: Costa, Ângela
Pinto, Filipe
Martinho, Olga
Oliveira, Maria José
Jordan, Peter
Reis, Rui Manuel
Palavras-chave: Vias de Transdução de Sinal e Patologias Associadas
Glioma
WNK2
MMP2
JNK
Tumor Suppressor
Data: Jan-2015
Editora: Impact Journals, LLC
Citação: Oncotarget. 2015 Jan 30;6(3):1422-34. doi: 10.18632/oncotarget.2805
Resumo: Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter methylation in gliomas. Patients without WNK2 exhibited poor prognosis, and its downregulation was associated with increased glioma cell invasion. Here we showed that MMP2 expression and activity are increased in glioma cell lines that do not express WNK2. Also, WNK2 inhibited JNK, a process associated with decreasing levels of MMP2. Thus, WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential.
Descrição: Free PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359304/
Peer review: yes
URI: http://hdl.handle.net/10400.18/3437
DOI: 10.18632/oncotarget.2805
ISSN: 1949-2553
Versão do Editor: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2805&pubmed-linkout=1
Aparece nas colecções:DGH - Artigos em revistas internacionais

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WNK2 silencing upregulates MMP2_JNK in glioma_Oncotarget.pdf6,46 MBAdobe PDFVer/Abrir


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