Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3391
Título: The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes
Autor: Botelho, M.C.
Alves, H.
Barros, A.M.
Rinaldi, G.
Brindley, P.J.
Sousa, M.
Palavras-chave: Schistosomiasis
Estrogen Receptor
Cancer
Infertility
Data: Jun-2015
Editora: Elsevier
Citação: Trends Parasitol. 2015 Jun;31(6):246-250. doi: 10.1016/j.pt.2015.03.005. Epub 2015 Mar 30.
Resumo: Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. Schistosomiasis haematobia also appears to negatively influence fertility, and is particularly associated with female infertility. Given that estrogens and estrogen receptors are key players in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to infertility through hormonal imbalances. Here, we review recent findings on the role of estrogens and estrogen receptors on both carcinogenesis and infertility associated with urogenital schistosomiasis and discuss the basic hormonal mechanisms that might be common in cancer and infertility.
URI: http://hdl.handle.net/10400.18/3391
DOI: 10.1016/j.pt.2015.03.005
ISSN: 1471-4922
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S147149221500046X
Aparece nas colecções:DPSPDNT - Artigos em revistas internacionais

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