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Repositório Científico do Instituto Nacional de Saúde >
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DPSPDNT - Artigos em revistas internacionais >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10400.18/332
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| Title: | Genome-wide linkage analyses of quantitative and categorical autism subphenotypes |
| Authors: | Liu, X.Q.
Paterson, A.D.
Szatmari, P.
Autism Genome Project Consortium |
| Keywords: | Autism
Genetic heterogeneity
IQ
Language
Linkage analysis
Schizophrenia
Perturbações do Desenvolvimento Infantil e Saúde Mental |
| Issue Date: | 1-Oct-2008 |
| Publisher: | Elsevier |
| Citation: | Biol Psychiatry. 2008 Oct 1;64(7):561-70. Epub 2008 Jul 16. |
| Abstract: | The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of autism since they may be more directly related to the underlying susceptibility loci. Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity. |
| Description: | Member of the Autism Genome Project Consortium: Astrid Moura Vicente |
| Peer Reviewed: | yes |
| URI: | http://hdl.handle.net/10400.18/332 |
| ISSN: | 0006-3223 |
| Publisher version: | http://www.sciencedirect.com/science/article/pii/S0006322308006860 |
| Appears in Collections: | DPSPDNT - Artigos em revistas internacionais
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