Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3282
Título: The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases
Autor: Bettencourt, Andreia
Carvalho, Cláudia
Leal, Bárbara
Brás, Sandra
Lopes, Dina
Martins da Silva, Ana
Santos, Ernestina
Torres, Tiago
Almeida, Isabel
Farinha, Fátima
Barbosa, Paulo
Marinho, António
Selores, Manuela
Correia, João
Vasconcelos, Carlos
Costa, Paulo P.
da Silva, Berta Martins
Palavras-chave: Dermatology and Venerology
Clinical Genetics
Internal Medicine
Rheumatology
Microbiology
immunology
Autoimmune Diseases
HLA
Immunogenetics
Clinical immunology
Doenças Genéticas
Determinantes da Saúde e da Doença
Data: 29-Out-2015
Editora: Hindawi Publishing Corporation
Citação: J Immunol Res. 2015;2015:948723. doi: 10.1155/2015/948723. Epub 2015 Oct 29
Resumo: Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls. We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98). We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58). Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1(∗)13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease. The protective effect of HLA-DRB1(∗)13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3282
DOI: 10.1155/2015/948723
ISSN: 2314-8861
Versão do Editor: www.hindawi.com/journals/jir/2015/948723/
Aparece nas colecções:DGH - Artigos em revistas internacionais

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