Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3156
Título: Bioaccessibility assessment of patulin and ochratoxin A in cereal and fruit based baby foods using a harmonized in vitro digestion model: contribution for the risk assessment of chemical mixtures
Autor: Assunção, Ricardo
Martins, Carla
Duarte, Elsa
Alvito, Paula
Palavras-chave: Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
Data: Set-2015
Resumo: People, animals and the environment can be exposed to multiple chemicals at once from a variety of sources, but current risk assessment is usually carried out on one chemical substance at a time. Mycotoxins are fungal natural contaminants commonly found in a variety of foods including baby foods and have been found in cereal and fruit based baby foods. In human health risk assessment, ingestion of food is considered a major route of exposure to many contaminants including mycotoxins, although the total amount of an ingested contaminant (external dose) does not always reflect the amount that is available to the body (internal dose). The amount of mycotoxin resisting to the digestion process and potentially absorbable by the systemic circulation is only a smaller part of that ingested. In vitro digestion models become useful for evaluating mycotoxins bioaccessibility during the intestinal transit and can be intended as a valuable tool for the assessment of mycotoxin bioavailability in food. Trichothecenes, Ochratoxin A (OTA) and Patulin (PAT) are the best known enteropathogenic mycotoxins able to alter functions of the intestine. OTA and PAT were previously detected in cereal and fruit based baby food. This study aimed to evaluate the bioaccessibility of the mycotoxins OTA and PAT in cereal and fruit based baby food and the possible interactions that could happen when these mycotoxins co-occur. A standardized static in vitro digestion method was used to assess the bioaccessibility of OTA and PAT in three different cereal and fruit based baby foods, previously checked not to be contaminated with these mycotoxins and artificially contaminated to 1 µg/kg of OTA and 20 µg/kg of PAT. Mycotoxins quantification was performed by HPLC-FLD for OTA and HPLC-UV for PAT. Preliminary results showed that PAT presented bioaccessibility values ranging from 42 % to 65 %. Bioaccessibility assays for OTA and the mixture of OTA and PAT are under process. This study will provide new information related with the bioaccessibility of mycotoxins in baby foods and the results will offer a more comprehensive picture of what occurs during the digestion of food contaminants in the gastrointestinal tract and subsequently contributes to provide a more accurate risk assessment of single and multiple food contaminants.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3156
DOI: 10.1016/j.toxlet.2015.08.375
Aparece nas colecções:DAN - Posters/abstracts em congressos internacionais



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