Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3129
Título: Macrophage iron metabolism profile in proatherogenic conditions
Autor: Canonne-Hergaux, François
Marques, Liliana
Negre-Salvayre, Anne
Costa, Luciana
Palavras-chave: Determinantes Imunológicos em Doenças Crónicas
Chronic Inflammatory Disease
Iron Metabolism
Data: Set-2015
Editora: Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
Resumo: Atherosclerosis is currently considered as a chronic inflammatory disease, in which the subendothelial accumulation of macrophages and their differentiation in lipid−laden foam cells through the uptake of oxidized LDL (oxLDL) constitute key events in atherogenesis [1]. In such process, iron could constitute a modifiable factor [2] and characterization of the iron metabolism profile of the different macrophages phenotypes present in atherosclerotic lesions may provide insight on their potential protective or proatherogenic role. A new macrophage phenotype (Mox) driven by exposure to oxidized phospholipids was recently described in murine models of atherosclerosis [3]. Herein, we investigated the effect of oxLDL as well as proinflammatory stimuli on macrophage polarization and iron metabolism profile.
URI: http://hdl.handle.net/10400.18/3129
Aparece nas colecções:DPSPDNT - Posters/abstracts em congressos internacionais

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