Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3110
Título: An overview of molecular basis of iron metabolism regulation and the associated pathologies
Autor: Silva, Bruno
Faustino, Paula
Palavras-chave: Iron Metabolism
Iron Overload
Iron
HFE
Hepcidin
Hereditary Haemochromatosis
Hemochromatosis
Anaemia
Post-transcriptional regulation
Doenças Genéticas
Data: Jul-2015
Editora: Elsevier
Citação: Biochim Biophys Acta. 2015 Jul;1852(7):1347-59. doi: 10.1016/j.bbadis.2015.03.011. Epub 2015 Apr 2
Resumo: Iron is essential for several vital biological processes. Its deficiency or overload drive to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, as the alternative splicing, microRNAs, the IRP/IREs system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3110
DOI: 10.1016/j.bbadis.2015.03.011
ISSN: 0006-3002
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0925443915001027
Aparece nas colecções:DGH - Artigos em revistas internacionais

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