Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3093
Título: Overview of proteomics studies in obstructive sleep apnea
Autor: Feliciano, Amélia
Torres, Vukosava M.
Vaz, Fatima
Carvalho, Ana Sofia
Matthiesen, Rune
Pinto, Paula
Malhotra, Atul
Bárbara, Cristina
Penque, Deborah
Palavras-chave: Sleep Apneia
Obstructive Sleep Apnea
Biomarkers
Proteomics
Mass Spectrometry
Lung
Metabolic Disorders
Genomica Funcional
Genómica Funcional e Estrutural
Data: Abr-2015
Editora: Elsevier/ World Association of Sleep Medicine and International Pediatric Sleep Association
Citação: Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14
Resumo: Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3093
DOI: 10.1016/j.sleep.2014.11.014
ISSN: 1389-9457
Versão do Editor: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402077/
http://www.sciencedirect.com/science/article/pii/S1389945715000775
Aparece nas colecções:DGH - Artigos em revistas internacionais

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