Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3069
Título: Beyond Cox-Inhibition: 'Side-Effects' of Ibuprofen on Neoplastic Development and Progression
Autor: Matos, Paulo
Jordan, Peter
Palavras-chave: Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
NSAID
Ibuprofen
Cell Signalling
Rac1b
Cancer Chemoprevention
Colorectal Cancer
Cyclooxygenase
Tumor Growth
Data: 10-Jun-2015
Editora: Bentham Science Publishers
Citação: Curr Pharm Des. 2015;21(21):2978-82
Resumo: Ibuprofen is a non-steroidal anti-inflammatory drug of generalized use with over-the-counter availability. Population-based studies have provided evidence that its long-term use is associated with a 30-60% decrease in the risk of developing major types of cancer. Initially, the underlying molecular mechanism was thought to be exclusively dependent on its inhibitory effect on cyclooxygenase activity, which is involved in the inflammatory response. However, numerous studies have now shown that the cancer chemopreventive properties of ibuprofen are much more complex and likely involve multiple COX-2-independent effects. Here we review the current knowledge on COX-independent effects of ibuprofen, which affect changes in gene expression or alternative splicing and act through various cell cycle- and apoptosis-regulating pathways, including β-catenin, NF-κB, PPARγ and p53.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3069
DOI: 10.2174/1381612821666150514104608
ISSN: 1381-6128
Versão do Editor: http://www.eurekaselect.com/131278/article
Aparece nas colecções:DGH - Artigos em revistas internacionais

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