Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2973
Título: Evolution, phylogeny, and molecular epidemiology of Chlamydia
Autor: Nunes, A.
Gomes, João Paulo
Palavras-chave: Chlamydia
Evolution
Phylogeny
Taxonomy
Molecular Epidemiology
Infecções Sexualmente Transmissíveis
Data: Abr-2014
Editora: Elsevier
Citação: Infect Genet Evol. 2014 Apr;23:49-64. doi: 10.1016/j.meegid.2014.01.029. Epub 2014 Feb 5
Resumo: The Chlamydiaceae are a family of obligate intracellular bacteria characterized by a unique biphasic developmental cycle. It encompasses the single genus Chlamydia, which involves nine species that affect a wide range of vertebral hosts, causing infections with serious impact on human health (mainly due to Chlamydia trachomatis infections) and on farming and veterinary industries. It is believed that Chlamydiales originated 700 mya, whereas C. trachomatis likely split from the other Chlamydiaceae during the last 6 mya. This corresponds to the emergence of modern human lineages, with the first descriptions of chlamydial infections as ancient as four millennia. Chlamydiaceae have undergone a massive genome reduction, on behalf of the deletional bias ‘‘use it or lose it’’, stabilizing at 1–1.2 Mb and keeping a striking genome synteny. Their phylogeny reveals species segregation according to biological properties, with huge differences in terms of host range, tissue tropism, and disease outcomes. Genome differences rely on the occurrence of mutations in the >700 orthologous genes, as well as on events of recombination, gene loss, inversion, and paralogous expansion, affecting both a hypervariable region named the plasticity zone, and genes essentially encoding polymorphic and transmembrane head membrane proteins, type III secretion effectors and some metabolic pathways. Procedures for molecular typing are still not consensual but have allowed the knowledge of molecular epidemiology patterns for some species as well as the identification of outbreaks and emergence of successful clones for C. trachomatis. This manuscript intends to provide a comprehensive review on the evolution, phylogeny, and molecular epidemiology of Chlamydia.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2973
DOI: 10.1016/j.meegid.2014.01.029
ISSN: 1567-1348
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S1567134814000422
Aparece nas colecções:DDI - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Nunes and Gomes_2014.pdf1,1 MBAdobe PDFVer/Abrir    Acesso Restrito. Solicitar cópia ao autor!


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.