Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2961
Título: GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples
Autor: Manageiro, Vera
Ferreira, Eugénia
Caniça, Manuela
Manaia, Célia M.
Palavras-chave: Resistência aos Antibióticos
Water
Ubiquitous Bacteria
β-lactamase
GES-5
Data: Fev-2014
Editora: John Wiley & Sons Ltd/ Federation of European Microbiological Societies
Citação: FEMS Microbiol Lett. 2014 Feb;351(1):64-69. doi: 10.1111/1574-6968.12340. Epub 2013 Dec 11
Resumo: In this study, we investigated the β-lactamase-encoding genes responsible for β-lactam resistance phenotypes detected among 56 Gram-negative isolates (Gamma- and Alpha-proteobacteria) recovered from wastewater, urban streams, and drinking water. The β-lactam resistance mechanisms detected in 36 isolates comprised the presence of class A (blaTEM-1, blaSHV-1, blaSHV-11, blaGES-5), class B (ImiS, L1), class C (blaCMY-2, blaCMY-34, blaCMY-65, blaCMY-89, blaCMY-90, blaACC-5, blaACT-13), and class D (blaOXA-309)β-lactamase-encoding genes, some variants described for the first time here. Notably, the results showed antimicrobial resistance genes related not only to commonly used antibiotics, but also to carbapenems, providing the first description of a GES-5-producing Enterobacteriaceae. The importance of ubiquitous bacteria thriving in aquatic environments as reservoirs or carriers of clinically relevant resistance determinants was confirmed, and the need to monitor water habitats as potential sources for the emergence and/or spread of antibiotic resistance in the environment was highlighted.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2961
DOI: 10.1111/1574-6968.12340
ISSN: 0378-1097
Versão do Editor: http://femsle.oxfordjournals.org/content/351/1/64.long
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