Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2936
Título: Nontuberculous mycobacteria pathogenesis and biofilm assembly
Autor: Sousa, Sara
Bandeira, Maria
Carvalho, Patricia Almeida
Duarte, Aida
Jordão, Luísa
Palavras-chave: Nontuberculous Mycobacteria (NTM)
Host-pathogen Interaction
Scanning Electron Microscopy (SEM)
Infecções Respiratórias
Data: 29-Jan-2015
Editora: Elsevier/ Asian-African Society for Mycobacteriology
Citação: Int J Mycobacteriol. 2015. doi: 10.1016/j.ijmyco.2014.11.065. Epub 2015 Jan 29
Resumo: Nontuberculous mycobacteria (NTM) are emergent pathogens whose importance in human health has been gaining relevance after being recognized as etiological agents of opportunist infections in HIV patients. Currently, NTM are recognized as etiological agents of several respiratory and extrarespiratory infections of immune-competent individuals. The environmental nature of NTM together with the ability to assemble biofilms on different surfaces plays a key role on their pathogenesis. In the present work the ability of three fast-growing NTM (M. smegmatis, M. fortuitum and M. chelonae) to persist within a model of human alveolar macrophages was evaluated. Most often human infections with NTM occur by contact with the environment. Biofilms can work as environmental reservoirs. For this reason, it was decided to evaluate the ability of NTM to assemble biofilms on different surfaces. Scanning electron microscopy was used to elucidate the biofilm structure. The ability to assemble biofilms was connected with the ability to spread on solid media known as sliding. Biofilm assembly and intracellular persistence seems to be ruled by different mechanisms.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2936
DOI: 10.1016/j.ijmyco.2014.11.065
ISSN: 2212-5531
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S221255311500045X
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