Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2929
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dc.contributor.authorVale, F.F.-
dc.contributor.authorOleastro, M.-
dc.identifier.citationWorld J Gastroenterol. 2014 May 21;20(19):5594-609. doi: 10.3748/wjg.v20.i19.5594por
dc.description.abstractHelicobacter pylori (H. pylori) successfully colonizes the human stomach of the majority of the human population. This infection always causes chronic gastritis, but may evolve to serious outcomes, such as peptic ulcer, gastric carcinoma or mucosa-associated lymphoid tissue lymphoma. H. pylori first line therapy recommended by the Maastricht-4 Consensus Report comprises the use of two antibiotics and a proton-pomp inhibitor, but in some regions failure associated with this treatment is already undesirable high. Indeed, treatment failure is one of the major problems associated with H. pylori infection and is mainly associated with bacterial antibiotic resistance. In order to counteract this situation, some effort has been allocated during the last years in the investigation of therapeutic alternatives beyond antibiotics. These include vaccines, probiotics, photodynamic inactivation and phage therapy, which are briefly revisited in this review. A particular focus on phytomedicine, also described as herbal therapy and botanical therapy, which consists in the use of plant extracts for medicinal purposes, is specifically addressed, namely considering its history, category of performed studies, tested compounds, active principle and mode of action. The herbs already experienced are highly diverse and usually selected from products with a long history of employment against diseases associated with H. pylori infection from each country own folk medicine. The studies demonstrated that many phytomedicine products have an anti-H. pylori activity and gastroprotective action. Although the mechanism of action is far from being completely understood, current knowledge correlates the beneficial action of herbs with inhibition of essential H. pylori enzymes, modulation of the host immune system and with attenuation of inflammation.por
dc.publisherBaishideng Publishing Grouppor
dc.subjectAlternative Treatmentpor
dc.subjectAntibiotic Resistancepor
dc.subjectBotanical Therapypor
dc.subjectHelicobacter pyloripor
dc.subjectHerb Medicinepor
dc.subjectHerbal Medicinepor
dc.subjectInfecções Gastrointestinaispor
dc.titleOverview of the phytomedicine approaches against Helicobacter pyloripor
degois.publication.titleWorld Journal of Gastroenterologypor
Aparece nas colecções:DDI - Artigos em revistas internacionais

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