Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2929
Título: Overview of the phytomedicine approaches against Helicobacter pylori
Autor: Vale, F.F.
Oleastro, M.
Palavras-chave: Alternative Treatment
Antibiotic Resistance
Botanical Therapy
Helicobacter pylori
Herb Medicine
Herbal Medicine
Phytomedicine
Phytotherapy
Probiotics
Infecções Gastrointestinais
Data: 21-Mai-2014
Editora: Baishideng Publishing Group
Citação: World J Gastroenterol. 2014 May 21;20(19):5594-609. doi: 10.3748/wjg.v20.i19.5594
Resumo: Helicobacter pylori (H. pylori) successfully colonizes the human stomach of the majority of the human population. This infection always causes chronic gastritis, but may evolve to serious outcomes, such as peptic ulcer, gastric carcinoma or mucosa-associated lymphoid tissue lymphoma. H. pylori first line therapy recommended by the Maastricht-4 Consensus Report comprises the use of two antibiotics and a proton-pomp inhibitor, but in some regions failure associated with this treatment is already undesirable high. Indeed, treatment failure is one of the major problems associated with H. pylori infection and is mainly associated with bacterial antibiotic resistance. In order to counteract this situation, some effort has been allocated during the last years in the investigation of therapeutic alternatives beyond antibiotics. These include vaccines, probiotics, photodynamic inactivation and phage therapy, which are briefly revisited in this review. A particular focus on phytomedicine, also described as herbal therapy and botanical therapy, which consists in the use of plant extracts for medicinal purposes, is specifically addressed, namely considering its history, category of performed studies, tested compounds, active principle and mode of action. The herbs already experienced are highly diverse and usually selected from products with a long history of employment against diseases associated with H. pylori infection from each country own folk medicine. The studies demonstrated that many phytomedicine products have an anti-H. pylori activity and gastroprotective action. Although the mechanism of action is far from being completely understood, current knowledge correlates the beneficial action of herbs with inhibition of essential H. pylori enzymes, modulation of the host immune system and with attenuation of inflammation.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2929
DOI: 10.3748/wjg.v20.i19.5594
ISSN: 1007-9327
Versão do Editor: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024768/
Aparece nas colecções:DDI - Artigos em revistas internacionais

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