Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2925
Título: Genotypic and phenotypic features of Arcobacter butzleri pathogenicity
Autor: Ferreira, S.
Queiroz, J.A.
Oleastro, M.
Domingues, F.C.
Palavras-chave: Adhesion
Arcobacter Butzleri
Inflammation
Intracellular Survival
Invasion
Virulence
Infecções Gastrointestinais
Data: Nov-2014
Editora: Elsevier/ Academic Press
Citação: Microb Pathog. 2014 Nov;76:19-25. doi: 10.1016/j.micpath.2014.09.004. Epub 2014 Sep 10
Resumo: Even though Arcobacter butzleri has been implicated in some human disease as diarrhoea and bacteraemia, much of its pathogenesis and virulence factors remain unclear. In this work we have compared pathogenic and genotypic properties of six A. butzleri isolates from human and non-human sources. The tested isolates showed to be susceptible to tetracyclines and aminoglycosides, however non-human isolates were all resistant to quinolones. The ability to form biofilms was variable among the tested strains, and all of them showed a weak haemolytic activity. The presence of nine putative virulence genes was determined, with cadF, ciaB, cj1349, mviN, pldA, tlyA being detected in all strains, while irgA (3/6), hecA (5/6), hecB (4/6) were detected only in some strains. High levels of adhesion were observed for A. butzleri on Caco-2 cells, with pre-existing inflammation showing no significant effect on the adherence ability; yet variable levels of invasion were observed. A. butzleri isolates were able to survive intracellularly in Caco-2 cells and to induce a significant up-regulation of interleukin-8 secretion and structural cell rearrangements. These data brings new insights on A. butzleri virulence and highlights its pathogenic potential.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2925
DOI: 10.1016/j.micpath.2014.09.004
ISSN: 0882-4010
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0882401014001284
Aparece nas colecções:DDI - Artigos em revistas internacionais



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