Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2899
Título: Molecular Epidemiology of Aspergillus collected from Cystic Fibrosis Patients
Autor: Sabino, R.
Ferreira, J.A.G.
Moss, R.B.
Valente, J.
Verissimo, C.
Carolino, E.
Clemons, K.V.
Everson, C.
Banaei, N.
Penner, J.
Stevens, D.A.
Palavras-chave: Cystic Fibrosis
Aspergillus
Cryptic Species
Infecções Sistémicas e Zoonoses
Data: 30-Out-2014
Editora: Elsevier/ European Cystic Fibrosis Society
Citação: J Cyst Fibros. 2015 Jul;14(4):474-81. doi: 10.1016/j.jcf.2014.10.005. Epub 2014 Oct 30.
Resumo: Background: Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function and allergic disease. Methods: Fifty-three Aspergillus isolates recovered fromCF patients were identified to species by Internal Transcribed Spacer Region (ITS), β-tubulin, and calmodulin sequencing. Results: Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found. Conclusions: To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A. fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic approach geared to this pathogen
Peer review: yes
URI: http://hdl.handle.net/10400.18/2899
DOI: 10.1016/j.jcf.2014.10.005
ISSN: 1569-1993
Aparece nas colecções:DDI - Artigos em revistas internacionais

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