Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2876
Título: The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
Autor: Bettencourt, A.
Martins Silva, A.
Carvalho, C.
Leal, B.
Santos, E.
Pinho-Costa, P.
Silva, B.
Palavras-chave: Multiple Sclerosis
Natural killer Cells
Doenças Genéticas
Data: 15-Abr-2014
Editora: Elsevier/ International Society for Neuroimmunology
Citação: J Neuroimmunol. 2014 Apr 15;269(1-2):52-5. doi: 10.1016/j.jneuroim.2014.01.009. Epub 2014 Jan 28
Resumo: Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2876
DOI: 10.1016/j.jneuroim.2014.01.009
ISSN: 0165-5728
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0165572814000125
Aparece nas colecções:DGH - Artigos em revistas internacionais

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