Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2842
Título: Dietary sodium intake related with cysteine and methionine in type 2 diabetic patients
Autor: Valente, A.
Bicho, M.
Duarte, R.
Raposo, J.F.
Costa, H.S.
Palavras-chave: Nutrição Aplicada
Estilos de Vida e Impacto na Saúde
Diabetes do tipo 2
Data: Mai-2014
Resumo: INTRODUCTION: In Portugal there are over a million diabetics. Most type 2 diabetic patients have salt sensitive hypertension but other cardiovascular risk factors can also be related with a high intake of dietary salt. AIM: To evaluate dietary sodium intake and its relation with homocysteine metabolism and oxidative state in type 2 diabetic patients with and without angiopathy. METHODS: A population-based case-control study in 300 Portuguese adults was performed. The study population was divided into three groups: group I - 75 type 2 diabetics with angiopathy, group II - 75 type 2 diabetics without angiopathy, group III - 150 controls. Plasma levels of homocysteine, cysteine and malondialdehyde were measured by HPLC. Dietary sodium and methionine intakes were assessed by a food frequency questionnaire. Statistical analysis was performed by linear regression model. RESULTS: The prevalence of dietary sodium intake above the recommended limit (2.0 g/day) was very high in all study groups (group I: 93,3% vs. group II: 93,3% vs. group III: 83,2%). Sodium intake was inversely associated with plasma cysteine levels (β = -0.299; t = -2.673; p = 0,009) in type 2 diabetic patients with angiopathy and positively related with methionine intake in diabetic and non-diabetic patients. CONCLUSION: All participants with high dietary sodium intake should initiate a sodium restriction diet that must be maintained at least during five weeks to lower the blood pressure to 130/85 mmHg. Since cysteine has been proposed to have an antihypertensive effect, diabetics with high dietary sodium intake, low plasma cysteine and hyperhomocysteinaemia have an increased risk of having another cardiovascular event. Adopting a balanced diet containing cysteine-rich proteins may be a beneficial lifestyle choice to prevent it.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2842
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