Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2753
Título: Development and Characterization of Engineered Acrylic Particulate Systems
Autor: Graça, Diogo
Ferreira, I.S.F.
Matos, A.
Gonçalves, L.M.D.
Silva, M.J.
Almeida, A.J.
Bettencourt, A.
Palavras-chave: Genotoxicidade Ambiental
Data: 2-Jul-2014
Resumo: Polymethylmethacrylate (PMMA) is one of the most widely explored biomaterials because of its biocompatibility. Recent publications have shown an increasing interest in its application as a carrier system in drug delivery[1]. A major drawback in its use refers to the incomplete drug release from PMMA particles. To improve release profiles, recent strategies are focusing on formulating PMMA composites with permeable polymers. The main aim of the study was to evaluate the effect of the incorporation of a specific permeable polymer - an Eudragit polymer (EUD) - to PMMA particles. Both PMMA and PMMA-EUD particles were obtained through simple emulsion solvent evaporation methodology (SESE), previously optimized in our group[1]. Comparison between particles was mainly focused on physicochemical properties with impact on drug release, including particle size, surface charge, hydrophobicity and chemical composition, which were conducted using suitable methods such as laser diffraction, zeta potential, hydrophobic interaction chromatography (HIC), Fourier Transform Infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM). SESE methodology allowed the production of particles with spherical and smooth surfaces within the micrometer range (PMMA = 572.7 ± 20 nm; PMMA-EUD = 508.9 ± 8 nm) with unimodal and narrow size distribution. Surface charge modification, as measured through zeta potential, was the main feature observed after inclusion of EUD in the formulation. Initial PMMA particles were strongly negative (-32.9±1.4 mV) whereas PMMA-EUD particles were strongly positive (+33.7±4.4 mV). The formulated PMMA-EUD particles also have shown slightly higher levels of hidrophobicity than the PMMA particles. Protein adsorption was also studied using a model protein (bovine serum albumin) through UV-Vis spectroscopy with both types of particles showing no considerable adsorption. The next step will be the evaluation of the effect of PMMA particles composition change in the release of a model drug. References: [1] Bettencourt, A., Almeida, A.J., J Microencapsul., 2012, 29(4):353-67.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2753
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