Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2674
Título: Estimates of 2012/13 influenza vaccine effectiveness using the case test-negative control design with different influenza negative control groups
Autor: Nunes, Baltazar
Machado, Ausenda
Guiomar, R.
Pechirra, P.
Conde, P.
Cristovão, P.
Falcão, I.
Palavras-chave: Influenza Vaccine
Case Test-negative Control Study
Other Respiratory Virus
Estados de Saúde e de Doença
Data: 31-Jul-2014
Editora: Elsevier
Citação: Vaccine. 2014 Jul 31;32(35):4443-9. doi: 10.1016/j.vaccine.2014.06.053. Epub 2014 Jun 21.
Resumo: Background: In recent years several reports of influenza vaccine effectiveness (VE) have been made early for public health decision. The majority of these studies use the case test-negative control design (TND), which has been showed to provide, under certain conditions, unbiased estimates of influenza VE. Nevertheless, discussions have been taken on the best influenza negative control group to use. The present study aims to contribute to the knowledge on this field by comparing influenza VE estimates using three test-negative controls: all influenza negative, non-influenza respiratory virus and pan-negative. Methods Incident ILI patients were prospectively selected and swabbed by a sample of general practitioners. Cases were ILI patients tested positive for influenza and controls ILI patients tested negative for influenza. The influenza negative control group was divided into non-influenza virus control group and pan-negative control group. Data were collected on vaccination status and confounding factors. Influenza VE was estimated as one minus the odds ratio of been vaccinated in cases versus controls adjusted for confounding effect by logistic regression. Results Confounder adjusted influenza VE against medically attended laboratory-confirmed influenza was 68.4% (95% CI: 20.7–87.4%) using all influenza negatives controls, 82.1% (95% CI: 47.6–93.9%) using non-influenza controls and 49.4% (95% CI: −44.7% to 82.3%) using pan-negative controls. Conclusions Influenza VE estimates differed according to the influenza negative control group used. These results are in accordance with the expected under the hypothesis of differential viral interference between influenza vaccinated and unvaccinated individuals. Given the wide importance of TND study further studies should be conducted in order to clarify the observed differences.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2674
DOI: 10.1016/j.vaccine.2014.06.053
ISSN: 0264-410X
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0264410X14008548
Aparece nas colecções:DEP - Artigos em revistas internacionais
DDI - Artigos em revistas internacionais

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