Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2403
Título: Exploring dangerous connections between Klebsiella pneumoniae biofilms and healthcare-associated infections
Autor: Bandeira, Maria
Carvalho, Patricia Almeida
Duarte, Aida
Jordão, Luísa
Palavras-chave: Biofilm
Scanning Electron Microscopy (SEM)
Healthcare-associated Infections (HAI)
Antibiotic Resistance
Infecções Respiratórias
Saúde Pública
Data: 19-Ago-2014
Editora: MDPI-Molecular Diversity Preservation International
Citação: Pathogens 2014, 3(3), 720-731; doi:10.3390/pathogens3030720
Resumo: Healthcare-associated infections (HAI) are a huge public health concern,particularly when the etiological agents are multidrug resistant. The ability of bacteria to develop biofilm is a helpful skill, both to persist within hospital units and to increase antibiotic resistance. Although the links between antibiotic resistance, biofilms assembly and HAI are consensual, little is known about biofilms. Here, electron microscopy was adopted as a tool to investigate biofilm structures associated with increased antibiotic resistance. The K. pneumoniae strains investigated are able to assemble biofilms, albeit with different kinetics. The biofilm structure and the relative area fractions of bacteria and extracellular matrix depend on the particular strain, as well as the minimal inhibitory concentration (MIC) for the antibiotics. Increased values were found for bacteria organized in biofilms when compared to the respective planktonic forms, except for isolates Kp45 and Kp2948, the MIC values for which remained unchanged for fosfomycin. Altogether, these results showed that the emergence of antimicrobial resistance among bacteria responsible for HAI is a multifactorial phenomenon dependent on antibiotics and on bacteria/biofilm features.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2403
DOI: 10.3390/pathogens3030720
ISSN: 2076-0817
Versão do Editor: http://www.mdpi.com/2076-0817/3/3/720/htm
Aparece nas colecções:DDI - Artigos em revistas internacionais

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