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Title: Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke
Authors: Manso, H.
Krug, T.
Sobral, J.
Albergaria, I.
Gaspar, G.
Ferro, J.M.
Oliveira, S.A.
Vicente, AM.
Keywords: Doenças Cardio e Cérebro-vasculares
Issue Date: 11-Mar-2010
Publisher: BioMed Central
Citation: BMC Med Genet. 2010 Mar 11;11:40
Abstract: Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.
ISSN: 1471-2350
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Appears in Collections:DPSPDNT - Artigos em revistas internacionais

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