Please use this identifier to cite or link to this item:
Title: Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke
Author: Manso, H.
Krug, T.
Sobral, J.
Albergaria, I.
Gaspar, G.
Ferro, J.M.
Oliveira, S.A.
Vicente, A.M.
Keywords: Doenças Cardio e Cérebro-vasculares
Issue Date: 11-Mar-2010
Publisher: BioMed Central
Citation: BMC Med Genet. 2010 Mar 11;11:40
Abstract: Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.
ISSN: 1471-2350
Publisher Version:
Appears in Collections:DPSPDNT - Artigos em revistas internacionais

Files in This Item:
File Description SizeFormat 
Variants of the Matrix Metalloproteinase-2 but not.pdf439,38 kBAdobe PDFView/Open

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.