Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2309
Título: Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium
Autor: Santos, J.
Gouveia, M.J.
Vale, N.
Delgado, M. de L.
Gonçalves, A.
da Silva, J.M.
Oliveira, C.
Xavier, P.
Gomes, P.
Santos, L.L.
Lopes, C.
Barros, A.
Rinaldi, G.
Brindley, P.J.
da Costa, J.M.
Sousa, M.
Botelho, M.C.
Palavras-chave: Schistosoma Haematobium
Estrogen Metabolites
Infertility
Data: Mai-2014
Editora: Public Library of Science
Citação: PLoS One. 2014 May 21;9(5):e96774. doi: 10.1371/journal.pone.0096774. eCollection 2014
Resumo: Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts. These catechol estrogens and the catechol-estrogen-DNA adducts can be isolated from sera of people infected with S. haematobium. The aim of this study was to study infertility in females infected with S. haematobium and its association with the presence of schistosome-derived catechol-estrogens.
URI: http://hdl.handle.net/10400.18/2309
ISSN: 1932-6203
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096774
Aparece nas colecções:DPSPDNT - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Urinary Estrogen Metabolites and Self-Reported Infertility.pdf2,23 MBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.