Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2223
Título: Human herpes virus 6B and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS): is there a link?
Autor: Leal, B.
Castelo Branco, R.
Rangel, R.
Chaves, J.
Carvalho, C.
Bettencourt, A.
Honavar, M.
Melo Pires, M.
Santos, A.
Magalhães, T.
Lopes, J.
Ramalheira, J.
Martins da Silva, A.
Costa, P.P.
Martins da Silva, B.
Palavras-chave: Epilepsy
MTLE
HHV-6
Febrile Seizures
Hippocampal Sclerosis
Determinantes da Saúde e da Doença
Doenças Genéticas
Data: 17-Jun-2013
Editora: Wiley/ International League Against Epilepsy
Citação: Epilepsia.2013;54(S3):135
Resumo: Purpose: Human Herpesvirus 6 (HHV-6) is a ubiquitous virus acquired mainly during the first 2 years of life. Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) is the most frequent pharmacoresistant epilepsy. One of the most common antecedents of MTLE-HS is febrile seizures (FS). Although the aetiology of MTLE-HS remains unclear, evidences suggest that HHV-6 infection could be implicated. The objective of this study was to investigate the presence of HHV-6B DNA in the hippocampus and adjoining temporal cortex of MTLE-HS patients submitted to surgery. Methods: A total of 22 MTLE-HS (13 females and nine males) cases were studied. The mean age at surgery was 39 9 years and mean age at onset of seizures was 10 6 years. These study cohort was compared to a group of 10 epileptic patients without MTLE-HS (six females, four males; mean age = 26 15 years) and with autopsy material from nine individuals without neurological disease. HHV-6B DNA was identified by real-time PCR with specific TaqMan probes. Results: We detected HHV-6B DNA in only one hippocampus from a MTLE-HS patient. This patient had a disease duration of 36 years and a history of febrile seizures in childhood. None of the non-MTLE or controls specimens showed positivity for HHV-6B. Conclusions: Our findings do not support a relevant etiologic role for HHV-6B in MTLE-HS, at least in this population. However, the possible role of viral infection in MTLE-HS epileptogenic process, in individual cases, cannot be excluded.
Peer review: no
URI: http://hdl.handle.net/10400.18/2223
ISSN: 0013-9580
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/epi.12229/pdf
Aparece nas colecções:DGH - Posters/abstracts em congressos internacionais

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