Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2216
Título: Is serotonin receptor HTR1B implicated in mesial temporal lobe epilepsy development?
Autor: Leal, B.
Barreira, A.
Chaves, J.
Carvalho, C.
Bettencourt, A.
Martins da Silva, A.
Costa, P.P.
Martins da Silva, B.
Palavras-chave: Epilepsy
MTLE
Serotonin
HTR1B
Genetic Association
Complex Disease Genetics
Determinantes da Saúde e da Doença
Doenças Genéticas
Data: 22-Set-2013
Editora: Elsevier/ World Federation of Neurology
Citação: J Neurol Sci. 2013;133(S1):e41
Resumo: Background: Evidences from animal models have demonstrated that depletion of brain serotonin (5-HT), a neurotransmitter with a pivotal role in neurodevelopment and brain plasticity, lowers the threshold to induced seizures. It was also demonstrated that anti-epileptic drugs increase endogenous 5-HT concentrations and that 5HT-1B receptors could have an anticonvulsant role. Association studies have demonstrated that a polymorphism (rs6296) in 5HTR-1B gene may be a susceptibility factor for with temporal lobe epilepsy (TLE) development. The rs6296 G allele has been associated with decreased receptor activity. Our aim was to analyse the association between rs6296 and the development and clinical features of Mesial Temporal Lobe Epilepsy (MTLE) in a Portuguese population. Material and methods: A cohort of 121 MTLE patients (67 F, 54 M, mean age = 44 ± 11 years, age of onset = 13 ± 9 years) was compared with a cohort of 192 healthy individuals (HI). All patients had Hippocampal Sclerosis (MTLE–HS). Genotyping was performed by TaqMan real time PCR methodology. Results: rs6296 G allele was overrepresented in MTLE patients compared to controls (80.2% in MTLE vs 72.1% in HI, p = 0.029 OR = 1.561 (1.060–2.298)). We constituted 2 MTLE–HS sub-groups, according to febrile seizure antecedents and no differences in rs6596 allelic or genotypic frequencies were found. Conclusion: The rs6296 G allele may be a susceptibility factor to MTLE–HS development. Since these receptors have an anticonvulsant role, a reduction in their activity could lower the threshold for seizure development.
Peer review: no
URI: http://hdl.handle.net/10400.18/2216
ISSN: 0022-510X
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0022510X13004607
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