Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2205
Título: Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)
Autor: Beirão, J.M.
Matos, M.E.
Beirão, I.B.
Costa, P.P.
Torres, P.A.
Palavras-chave: Familial Amyloidotic Polyneuropathy
Eye Disease
Dry Eye
Cyclosporine
Liver Transplantation
Doenças Genéticas
Data: 26-Set-2013
Editora: Wichtig Editore
Citação: Eur J Ophthalmol. 2013 Mar-Apr;23(2):156-63. doi: 10.5301/ejo.5000197
Resumo: PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs. METHODS: A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months. RESULTS: Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events. CONCLUSIONS: Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2205
ISSN: 1120-6721
Versão do Editor: http://www.eur-j-ophthalmol.com/article/topical-cyclosporine-for-severe-dry-eye-disease-in-liver-transplanted-portuguese-patients-with-familial-amyloidotic-polyneuropathy--attrv30m-
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