Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2204
Título: The use of intravitreal ranibizumab to treat neovascular glaucoma because of retinal amyloid angiopathy in familial amyloidosis transthyretin V30M related
Autor: Beirão, N.M.
Miranda, V.
Beirão, I.
Costa, P.P.
Torres, P.
Palavras-chave: Polineuropatia Amiloidótica Familiar
ATTR V30M
Glaucoma
Retinal Amyloid Angiopathy
Ocular Disease
Ranibizumab
Case Report
Doenças Genéticas
Data: 2013
Editora: Lippincott, Williams & Wilkins
Citação: Retinal Cases & Brief Reports. 2013;7(1):114-116
Resumo: Purpose: The purpose of this study to report a patient with amyloidotic angiopathy and neovascular glaucoma who was treated with intravitreal injection of ranibizumab followed by laser photocoagulation. Methods: A 52-year-old liver-transplanted woman with familial amyloidotic polyneuropathy presented with unilateral rubeosis iridis and neovascular glaucoma. A complete ocular examination and fluorescein and indocyanine green angiography were performed. Results: Best-corrected visual acuity before injection was 0.05 (Snellen) in the left eye, and intraocular pressure was 42 mmHg. Fluorescein angiography showed vascular occlusion in the retinal periphery, focal staining of vessels, and microaneurysms. Indocyanine green angiography showed hyperfluorescent spots alongside the choroidal veins. Two days after receiving intravitreal injection of ranibizumab, the clinical picture regressed. The diagnosis of retinal amyloid angiopathy was made, and a peripheral retinal laser photocoagulation was done. The final best-corrected visual acuity after 2 years of follow-up was 0.4 (Snellen) in the left eye. Conclusion: Intravitreal injections of ranibizumab should be evaluated for a potential role on the treatment of amyloid angiopathy neovascular glaucoma. Careful retinal periphery examination should be included in the ophthalmologic examination of all familial amyloidotic polyneuropathy patients.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2204
ISSN: 1935-1089
Versão do Editor: http://journals.lww.com/retinalcases/pages/articleviewer.aspx?year=2013&issue=00710&article=00032&type=abstract
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