Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/2202
Título: CCR5-Delta32: Implications in SLE development
Autor: Carvalho, C.
Calvisi, S.L.
Leal, B.
Bettencourt, A.
Marinho, A.
Almeida, I.
Farinha, F.
Pinho-Costa, P.
Silva, B.M.
Vasconcelos, C.
Palavras-chave: Systemic Lupus Erythematosus
CCR5
Autoimmune Diseases
Genetic Association
Complex Disease Genetics
Data: 29-Out-2013
Editora: John Wiley & Sons Ltd
Citação: Int J Immunogenet. 2014 Jun;41(3):236-41. doi: 10.1111/iji.12094. Epub 2013 Oct 29
Resumo: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the clinical course of the disease. The aim of this study was to evaluate the possible association between the CCR5{increment}32 base-pair deletion polymorphism and SLE disease in a group of Portuguese patients. A total of 219 patients with SLE and 205 healthy individuals were studied. The frequency of CCR5[del]32 heterozygotes was lower in patients with SLE than in controls (8% vs. 15% OR = 0.5162; P = 0.0319), suggesting a protective association between CCR5[del]32 allele and SLE. These results highlight the protective role of Th1 cells that express CCR5 in SLE pathogenesis.
Peer review: yes
URI: http://hdl.handle.net/10400.18/2202
ISSN: 1744-3121
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/iji.12094/pdf
Aparece nas colecções:DGH - Artigos em revistas internacionais

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