Repositório Científico do Instituto Nacional de Saúde >
Departamento de Doenças Infecciosas >
DDI - Artigos em revistas internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/208

Título: Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain
Autor: Andrade, Helena Rebelo de
Pereira, Cristiana
Gíria, Marta
Prudêncio, Ema
Brito, Maria João
Calé, Etelvina
Taveira, Nuno
Palavras-chave: Resistência aos Antimicrobianos
Adenovirus
Issue Date: Apr-2010
Editora: American Society for Microbiology.
Citação: J Clin Microbiol. 2010 Apr;48(4):1391-6. Epub 2010 Feb 10
Resumo: Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most (96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential.
Arbitragem científica: yes
URI: http://hdl.handle.net/10400.18/208
ISSN: 0095-1137
Versão do Editor: http://jcm.asm.org/cgi/content/full/48/4/1391?view=long&pmid=20147640
Appears in Collections:DDI - Artigos em revistas internacionais

Files in This Item:

File Description SizeFormat
Outbreak of acute respiratory infection among infants in Lisbon.pdf491,1 kBAdobe PDFView/Open

Please give feedback about this item
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

  © 2010 www.insa.pt - Todos os direitos reservados | Feedback Ministério da Saúde
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia