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Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/206

Título: Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
Autor: Grundmann, H.
Livermore, D. M.
Giske, C. G.
Canton, R.
Rossolini, G. M.
Campos, J.
Vatopoulos, A.
Gniadkowski, M.
Toth, A.
Pfeifer, Y.
Jarlier, V.
Carmeli, Y.
The CNSE Working Group
Palavras-chave: Enterobacteriaceae
Carbapenem
Resistência aos Antimicrobianos
Issue Date: 18-Nov-2010
Editora: European Centre for Disease Prevention and Control
Citação: Euro Surveill. 2010 Nov 18;15(46). pii: 19711
Resumo: The emergence and global spread of carbapenemase-producing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiology is compounded by the diversity of carbapenem-hydrolysing enzymes and the ability of their genes to spread between different bacterial species. Difficulties are also encountered by laboratories when trying to detect carbapenemase production during routine diagnostic procedures due to an often heterogeneous expression of resistance. Some of the resistance genes are associated with successful clonal lineages which have a selective advantage in those hospitals where antimicrobial use is high and opportunities for transmission exist; others are more often associated with transmissible plasmids. A genetically distinct strain of Klebsiella pneumoniae sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) has been causing epidemics of national and international proportions. It follows the pathways of patient referrals, causing hospital outbreaks along the way. Simultaneously, diverse strains harbouring New Delhi metallo-beta-lactamase (NDM-1) are repeatedly being imported into Europe, commonly via patients with prior medical exposure in the Indian subcontinent. Since the nature and scale of carbapenem-non-susceptible Entrobacteriaceae as a threat to hospital patients in Europe remains unclear, a consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner.
Descrição: The CNSE Working Group: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)
Erratum in Euro Surveill. 2011;16(5). pii: 19781. Euro Surveill. 2011;16(3). pii: 19766. Garcia Fernandez, Aurora [corrected to Garcia-Fernandez, Aurora]; Leverstein, Maurine [corrected to Leverstein-van Hall, Maurine A]. Euro Surveill. 2010 Nov 25;15(47)pii: 19726. Euro Surveill. 2010;15(50). pii: 19755.
Comment in Euro Surveill. 2010;15(50). pii: 19752
Arbitragem científica: yes
URI: http://hdl.handle.net/10400.18/206
ISSN: 1025-496X
Versão do Editor: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19711
Appears in Collections:DDI - Artigos em revistas internacionais

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