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Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/205

Title: New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe
Authors: Struelens, M. J.
Monnet, D. L.
Magiorakos, A. P.
O’Connor, F. Santos
Giesecke, J .
The European NDM-1 Survey Participants
Keywords: Beta-lactamase
Enterobacteriaceae
Resistência aos Antimicrobianos
Issue Date: 18-Nov-2010
Publisher: European Centre for Disease Prevention and Control
Citation: Euro Surveill. 2010 Nov 18;15(46). pii: 19716
Abstract: Acquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat. A novel acquired carbapenemase, New Delhi metallo-beta-lactamase 1 (NDM-1), has recently been described in the United Kingdom and Sweden, mostly in patients who had received care on the Indian subcontinent. We conducted a survey among 29 European countries (the European Union Member States, Iceland and Norway) to gather information on the spread of NDM-1-producing Enterobacteriaceae in Europe, on public health responses and on available national guidance on detection, surveillance and control. A total of 77 cases were reported from 13 countries from 2008 to 2010. Klebsiella pneumoniae was the most frequently reported species with 54%. Among 55 cases with recorded travel history, 31 had previously travelled or been admitted to a hospital in India or Pakistan and five had been hospitalised in the Balkan region. Possible nosocomial acquisition accounted for 13 of 77 cases. National guidance on NDM-1 detection was available in 14 countries and on NDM-1 control in 11 countries. In conclusion, NDM-1 is spreading across Europe, where it is frequently linked to a history of healthcare abroad, but also to emerging nosocomial transmission. National guidance in response to the threat of carbapenemase-producing Enterobacteriaceae is available in approximately half of the surveyed European countries. Surveillance of carbapenemase- producing Enterobacteriaceae must be enhanced in Europe and effective control measures identified and implemented.
Description: The European NDM-1 Survey Participants: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)
Peer Reviewed: yes
URI: http://hdl.handle.net/10400.18/205
ISSN: 1025-496X
Publisher version: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19716
Appears in Collections:DDI - Artigos em revistas internacionais

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