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Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/201

Title: Schistosoma haematobium: identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells
Authors: Botelho, Mónica Catarina
Soares, Raquel
Vale, Nuno
Ribeiro, Ricardo
Camilo, Vânia
Almeida, Raquel
Medeiros, Rui
Gomes, Paula
Machado, José Carlos
Costa, José Manuel Correia da
Keywords: Schistosoma haematobium
Estradiol
Estrogen receptor
MCF-7 cells
CHO cells
Estrogenic molecules
Mass spectrometry
Infecções Sistémicas e Zoonoses
Issue Date: Dec-2010
Publisher: Elsevier
Citation: Exp Parasitol. 2010 Dec;126(4):526-35. Epub 2010 Jun 12.
Abstract: We have previously identified the expression of an estradiol (E2)-related molecule by Schistosoma haematobium total antigen (Sh). We now show that this molecule has an antagonistic effect of estradiol in vitro. Our results are consistent with the existence of an estrogenic molecule that antagonizes the activity of estradiol. We found evidence for this molecule as we identified and characterized by mass spectrometry new estrogenic molecules previously unknown, present in schistosome worm extracts and sera of Schistosoma-infected individuals. We also show that Sh is able to interact in vitro with estrogen receptor (ER), explaining how host endocrine system can favor the establishment of schistosomes. These findings highlight the exploitation of the host endocrine system by schistosomes and represent an additional regulatory component of schistosome development that defines a novel paradigm enabling host–parasite interactions. The identification of these molecules opens new ways for the development of alternative drugs to treat schistosomiasis.
Peer Reviewed: yes
URI: http://hdl.handle.net/10400.18/201
ISSN: 0014-4894
Publisher version: http://www.sciencedirect.com/science/article/pii/S0014489410002079
Appears in Collections:DDI - Artigos em revistas internacionais

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