Repositório Científico do Instituto Nacional de Saúde >
Departamento de Doenças Infecciosas >
DDI - Artigos em revistas internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/198

Title: Schistosoma haematobium and bladder cancer: what lies beneath?
Authors: Botelho, Mónica Catarina
Machado, José Carlos
Costa, José Manuel Correia da
Keywords: Schistosoma haematobium
Squamous cell carcinoma of the bladder
CHO cells
Carcinogenesis-associated
Animal models
Kras mutations
Estrogenic DNA adducts
Infecções Sistémicas e Zoonoses
Issue Date: Mar-2010
Publisher: Landes Bioscience
Citation: Virulence. 2010 Mar-Apr;1(2):84-7
Abstract: Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associated phenotypes in CHO cells exposed to Sh total antigen, in which we showed increased cell proliferation, decreased apoptosis, up regulation of the anti-apoptotic molecule Bcl-2, down regulation of the tumor suppressor protein p27, and increased cell migration and invasion. We further discuss the molecular and cellular events that might be responsible for schistosomiasis-related bladder cancer.
Peer Reviewed: yes
URI: http://hdl.handle.net/10400.18/198
ISSN: 2150-5594
Publisher version: http://www.landesbioscience.com/journals/virulence/article/10487/
Appears in Collections:DDI - Artigos em revistas internacionais

Files in This Item:

File Description SizeFormat
Schistosoma haematobium and bladder cancer.pdf516.2 kBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

  © 2010 www.insa.pt - Todos os direitos reservados | Feedback Ministério da Saúde

Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE