Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/1876
Título: Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract
Autor: Vale, N.
Gouveia, M.J.
Botelho, M.
Sripa, B.
Suttiprapa, S.
Rinaldi, G.
Gomes, P.
Brindley, P.J.
Correia da Costa, J.M.
Palavras-chave: Bile Acids
Flukes
Opisthorchis Viverrini
Oxysterols
Data: 20-Ago-2013
Editora: Elsevier/ Japanese Society of Parasitology
Citação: Parasitol Int. 2013 Dec;62(6):535-42. doi: 10.1016/j.parint.2013.08.001. Epub 2013 Aug 20.
Resumo: Liquid chromatography in tandem mass spectrometry (LC-MS/MS) has emerged as an informative tool to investigate oxysterols (oxidized derivatives of cholesterol) in helminth parasite associated cancers. Here, we used LC-MS/MS to investigate in soluble extracts of the adult developmental stage of Opisthorchis viverrini from experimentally infected hamsters. Using comparisons with known bile acids and the metabolites of estrogens, the LC-MS data indicated the existence of novel oxysterol derivatives in O. viverrini. Most of these derivatives were ramified at C-17, in similar fashion to bile acids and their conjugated salts. Several were compatible with the presence of an estrogen core, and/or hydroxylation of the steroid aromatic ring A, hydroxylation of both C-2 and C-3 of the steroid ring and further oxidation into an estradiol-2,3-quinone.
Peer review: yes
URI: http://hdl.handle.net/10400.18/1876
ISSN: 1383-5769
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S1383576913001165#
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