Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/1734
Título: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Autor: Cross-Disorder Group of the Psychiatric Genomics Consortium
International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Palavras-chave: Perturbações do Desenvolvimento Infantil e Saúde Mental
Psychiatric Disorders
SNPs
Data: 28-Ago-2013
Editora: Nature Publishing Group
Citação: Nat Genet. 2013 Aug 28;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11.
Resumo: Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Descrição: AM Vicente - Cross-Disorder Group of the Psychiatric Genomics Consortium
Peer review: yes
URI: http://hdl.handle.net/10400.18/1734
ISSN: 1061-4036
Versão do Editor: http://www.nature.com/ng/journal/v45/n9/full/ng.2711.html
Aparece nas colecções:DPSPDNT - Artigos em revistas internacionais



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