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Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/160

Title: Tuberculosis: new aspects of an old disease
Authors: Jordao, Luisa
Vieira, Otilia V.
Keywords: Infecções Respiratórias
Issue Date: Jun-2011
Publisher: Hindawi Publishing Corporation
Citation: Int J Cell Biol. 2011;2011:403623. Epub 2011 Jun 21
Abstract: Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculosis interference with phagosomematuration, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade.
Peer Reviewed: yes
URI: http://hdl.handle.net/10400.18/160
ISSN: 1687-8884
Publisher version: http://www.hindawi.com/journals/ijcb/2011/403623/
Appears in Collections:DDI - Artigos em revistas internacionais

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