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Title: Tuberculosis: new aspects of an old disease
Authors: Jordão, Luísa
Vieira, Otilia V.
Keywords: Infecções Respiratórias
Issue Date: Jun-2011
Publisher: Hindawi Publishing Corporation
Citation: Int J Cell Biol. 2011;2011:403623. Epub 2011 Jun 21
Abstract: Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculosis interference with phagosomematuration, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade.
Peer review: yes
ISSN: 1687-8884
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Appears in Collections:DDI - Artigos em revistas internacionais

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