Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/1587
Título: Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals
Autor: Parreira, R.
Monteiro, F.
Pádua, E.
Piedade, J.
Venenno, T.
Paixão, M.T.
Esteves, A.
Palavras-chave: HIV-2
Pol Sequences
Polymorphisms
Drug-naive
Portugal
Infecções Sexualmente Transmissíveis
Data: Nov-2006
Editora: Mary Ann Liebert / International Retrovirology Association
Citação: AIDS Res Hum Retroviruses. 2006 Nov;22(11):1178-82
Resumo: Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.
Peer review: yes
URI: http://hdl.handle.net/10400.18/1587
ISSN: 0889-2229
Versão do Editor: http://online.liebertpub.com/doi/abs/10.1089/aid.2006.22.1178
Aparece nas colecções:DDI - Artigos em revistas internacionais

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