Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/1555
Título: Spectrum of congenital anomalies in pregnancies with pregestational diabetes
Autor: Garne, Ester
Loane, Maria
Dolk, Helen
Barisic, Ingeborg
Addor, Marie-Claude
Arriola, Larraitz
Bakker, Marian
Calzolari, Elisa
Dias, Carlos Matias
Doray, Berenice
Gatt, Miriam
Melve, Kari Klyungsoyr
Nelen, Vera
O’Mahony, Mary
Pierini, Anna
Randrianaivo-Ranjatoelina, Hanitra
Rankin, Judith
Rissmann, Anke
Tucker, David
Verellun-Dumoulin, Christine
Wiesel, Awi
Palavras-chave: Pregestational Diabetes
Congenital Anomalies
Population Based
Livebirths
Europe
Estados de Saúde e de Doença
Data: Mar-2012
Editora: Wiley-Blackwell
Citação: Birth Defects Res A Clin Mol Teratol. 2012 Mar;94(3):134-40. doi: 10.1002/bdra.22886. Epub 2012 Feb 28
Resumo: Maternal pregestational diabetes is a well-known risk factor for congenital anomalies. This study analyses the spectrum of congenital anomalies associated with maternal diabetes using data from a large European database for the population-based surveillance of congenital anomalies. METHODS: Data from 18 population-based EUROCAT registries of congenital anomalies in 1990-2005. All malformed cases occurring to mothers with pregestational diabetes (diabetes cases) were compared to all malformed cases in the same registry areas to mothers without diabetes (non-diabetes cases). RESULTS: There were 669 diabetes cases and 92,976 non diabetes cases. Odds ratios in diabetes pregnancies relative to non-diabetes pregnancies comparing each EUROCAT subgroup to all other non-chromosomal anomalies combined showed significantly increased odds ratios for neural tube defects (anencephaly and encephalocele, but not spina bifida) and several subgroups of congenital heart defects. Other subgroups with significantly increased odds ratios were anotia, omphalocele and bilateral renal agenesis. Frequency of hip dislocation was significantly lower among diabetes (odds ratio 0.15, 95% CI 0.05–0.39) than non-diabetes cases. Multiple congenital anomalies were present in 13.6 % of diabetes cases and 6.1 % of non-diabetes cases. The odds ratio for caudal regression sequence was very high (26.40, 95% CI 8.98–77.64), but only 17% of all caudal regression cases resulted from a pregnancy with pregestational diabetes. CONCLUSIONS: The increased risk of congenital anomalies in pregnancies with pregestational diabetes is related to specific non-chromosomal congenital anomalies and multiple congenital anomalies and not a general increased risk.
Peer review: yes
URI: http://hdl.handle.net/10400.18/1555
ISSN: 1542-0760
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/bdra.22886/pdf
Aparece nas colecções:DEP - Artigos em revistas internacionais

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