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|Title: ||Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers|
|Authors: ||Alves, Joana|
Rosário, Virgílio Estólio do
Arez, Ana Paula
|Keywords: ||Hemoglobin S|
|Issue Date: ||15-Jan-2010|
|Citation: ||Blood Cells Mol Dis. 2010 Jan 15;44(1):62-8. Epub 2009 Oct 17|
|Abstract: ||Malaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization.
Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World
Health Organization, studies have highlight the prospect of malaria becoming a serious public health
problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite
populations and underscore the need for tighter surveillance.
Despite the presumptive weak immune status of the population, severe symptoms of malaria are not
observed and many people present a subclinical course of the disease. No data on the prevalence of sicklecell
trait and red cell glucose-6-phosphate dehydrogenase deficiency (two classical genetic factors associated
with resistance to severe malaria) were available for the Cabo Verde archipelago and, therefore, we studied
the low morbidity from malaria in relation to the particular genetic characteristics of the human host
population. We also included the analysis of the pyruvate kinase deficiency associated gene, reported as
putatively associated with resistance to the disease.
Allelic frequencies of the polymorphisms examined are closer to European than to African populations and
no malaria selection signatures were found. No association was found between the analyzed human factors
and infection but one result is of high interest: a linkage disequilibrium test revealed an association of distant
loci in the PKLR gene and adjacent regions, only in non-infected individuals. This could mean a more
conserved gene region selected in association to protection against the infection and/or the disease.|
|Peer Reviewed: ||yes|
|Publisher version: ||http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBV-4XGCHXY-1-4&_cdi=6720&_user=2460193&_pii=S1079979609001752&_origin=&_coverDate=01%2F15%2F2010&_sk=999559998&view=c&wchp=dGLzVlz-zSkzV&md5=21ed902ea786acab8ce255c33febf851&ie=/sdarticle.pdf|
|Appears in Collections:||DGH - Artigos em revistas internacionais|
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