Repositório Científico do Instituto Nacional de Saúde >
Departamento de Genética Humana >
DGH - Artigos em revistas internacionais >
Please use this identifier to cite or link to this item:
|Título: ||HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis|
|Autor: ||Bettencourt, A|
|Issue Date: ||24-Jun-2010|
|Citação: ||Eur J Neurol. Epub 2010 Jun 24|
|Resumo: ||Background: High iron concentrations have been reported in oligodendrocytes,
myelin and macrophages in multiple sclerosis (MS) lesions. It has been proposed that
HFE gene polymorphisms could have a role in MS.
Methods: The C282Y and H63D HFE variants frequencies were determined in 373
patients with MS and compared with a normal population.
Results: No significant association was found between HFE polymorphisms and
disease susceptibility. An analysis of the association of genotypes with disease severity
was performed, and the C282Y allele was more frequent in the aggressive group.
Conclusions: Patients carrying the C282Y variant seem to have a worse prognosis.|
|Descrição: ||Versão impressa: Eur J Neurol. 2011 Apr;18(4):663-6|
|Arbitragem científica: ||yes|
|Versão do Editor: ||http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2010.03109.x/abstract|
|Appears in Collections:||DGH - Artigos em revistas internacionais|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.