Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/122
Título: HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis
Autor: Bettencourt, A
Silva, AM
Santos, E
Gomes, S
Mendonça, D
Costa, PP
Faustino, Paula
Silva, BM
Palavras-chave: HFE
multiple sclerosis
Portugal
severity
susceptibility
Doenças Genéticas
Data: 24-Jun-2010
Citação: Eur J Neurol. Epub 2010 Jun 24
Resumo: Background: High iron concentrations have been reported in oligodendrocytes, myelin and macrophages in multiple sclerosis (MS) lesions. It has been proposed that HFE gene polymorphisms could have a role in MS. Methods: The C282Y and H63D HFE variants frequencies were determined in 373 patients with MS and compared with a normal population. Results: No significant association was found between HFE polymorphisms and disease susceptibility. An analysis of the association of genotypes with disease severity was performed, and the C282Y allele was more frequent in the aggressive group. Conclusions: Patients carrying the C282Y variant seem to have a worse prognosis.
Descrição: Versão impressa: Eur J Neurol. 2011 Apr;18(4):663-6
Peer review: yes
URI: http://hdl.handle.net/10400.18/122
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2010.03109.x/abstract
Aparece nas colecções:DGH - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
HFE gene polymorphisms and severity.pdf76,7 kBAdobe PDFVer/Abrir    Acesso Restrito. Solicitar cópia ao autor!


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.