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|Title: ||Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?|
|Authors: ||Navarro-Costa, Paulo|
Plancha, Carlos E.
|Keywords: ||Doenças Genéticas|
|Issue Date: ||2010|
|Publisher: ||Hindawi Publishing Corporation|
|Citation: ||J Biomed Biotechnol. 2010;2010:936569. Epub 2010 Jun 30|
|Abstract: ||The azoospermia factor (AZF) regions consist of three genetic domains in the long arm of the human Y chromosome referred to
as AZFa, AZFb and AZFc. These are of importance for male fertility since they are home to genes required for spermatogenesis.
In this paper a comprehensive analysis of AZF structure and gene content will be undertaken. Particular care will be given to
the molecular mechanisms underlying the spermatogenic impairment phenotypes associated to AZF deletions. Analysis of the 14
different AZF genes or gene families argues for the existence of functional asymmetries between the determinants; while some are
prominent players in spermatogenesis, others seem to modulate more subtly the program. In this regard, evidence supporting the
notion that DDX3Y, KDM5D, RBMY1A1, DAZ, and CDY represent key AZF spermatogenic determinants will be discussed.|
|Peer Reviewed: ||yes|
|Appears in Collections:||DGH - Artigos em revistas internacionais|
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