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Title: Isolation and identification of Bacillus strains with antimycobacterial activity
Author: El Guendouzi, Souraya
David, Susana
Mohammed, Hassi
Abdellatif, Haggoud
Saad Ibn, Souda
Abdellah, Houari
Mohammed, Iraqui
Keywords: Infecções Respiratórias
Resistência aos Antimicrobianos
Antimycobacterial Agents
Issue Date: 9-Oct-2011
Publisher: Academic Journals
Citation: AfricanJ Microbiol Res. 9 Oct 2011;5(21):3468-3474
Abstract: Tuberculosis is the principal cause of death worldwide due to an infectious disease. The resurgence of tuberculosis, followed by the increase in prevalence of infections caused by nontuberculous mycobacteria (NTM), as well as the multi-drug resistance of mycobacteria to the majority of currently available antibiotics, have encouraged research for new antimycobacterial agents. Soil and water samples from different Moroccan biotopes, have led to the isolation of four bacterial strains (M, R, G and S), showing an inhibitory effect on mycobacterial growth. This effect was shown to be due to secreted substances in the growth medium. From subsequent analysis it was concluded that these strains produced different active substances. Sequencing of the 16S rRNA showed that these isolates belong to the genus Bacillus. The active substance from isolate M, showed the more important inhibitory effect on mycobacterial growth. It is precipitated with ammonium sulfate and lost all activity when treated with Proteinase K, revealing its protein nature.
Peer review: yes
ISSN: 1996-0808
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Appears in Collections:DGH - Artigos em revistas internacionais

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