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Title: Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface
Authors: Marques, L.
Auriac, A.
Willemetz, A.
Banha, J.
Silva, B.
Canonne-Hergaux, F.
Costa, L.
Keywords: GPI-ceruloplasmin
Lipid Raft
Immune Cells
Iron Metabolism
Determinantes Imunológicos em Doenças Crónicas
Issue Date: Feb-2012
Publisher: Elsevier
Citation: Blood Cells Mol Dis. 2012 Feb 15;48(2):110-20. Epub 2011 Dec 16.
Abstract: Ceruloplasmin is a positive acute-phase protein with both anti- and pro-oxidant activities, thus having still unclear physiological functions in inflammatory processes. Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux. Ceruloplasmin can be expressed as a secreted or as a membrane glycosylphosphatidylinositol-anchored protein (GPI-ceruloplasmin), this latter one being reported as expressed mostly in the brain.
ISSN: 1079-9796
Publisher Version:
Appears in Collections:DPSPDNT - Artigos em revistas internacionais

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