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Title: In vitro and intracellular antimycobacterial activity of a Bacillus pumilus strain
Authors: Hassi, Mohammed
David, Suzanna
Haggoud, Abdellatif
El Guendouzi, Souraya
El Ouarti, Asmae
Ibn Souda, Saad
Iraqui, Mohammed
Keywords: Drug Resistance of Tuberculosis Bacilli
Antimycobacterial Agents
Bacillus Pumilus
Resistência aos Antimicrobianos
Issue Date: 25-Jan-2012
Publisher: Academic Journals
Citation: African Journal of Microbiology Research 2012;6(10):2299-2304
Abstract: Despite the declaration of tuberculosis (TB) as a global emergency by the world health organization (WHO) about 20 years ago, the worldwide problem of this disease has worsened due to increased drug resistance of tuberculosis bacilli and acquired immune deficiency syndrome (AIDS) pandemic. Consequently, fight against multidrug and extensively drug-resistant TB is a high priority for public health and research. The present work describes the isolation of a Bacillus pumilus strain secreting a metabolite of protein nature capable of inhibiting mycobacterial growth (Mycobacterium smegmatis, Mycobacterium aurum and Mycobacterium bovis BCG). This metabolite is not toxic, accumulates within the macrophage and inactivates the bacilli with a comparable efficiency to that of the pure commercial antimycobacterial substance Amikacin.
Peer review: yes
ISSN: 1996-0808
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Appears in Collections:DGH - Artigos em revistas internacionais

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