http://hdl.handle.net/10400.18/5 Fri, 31 May 2013 00:33:13 GMT 2013-05-31T00:33:13Z http://hdl.handle.net/10400.18/1584 Title: Hypercholesterolemia: A disease with expression from childhood Authors: Espinheira, M.C.; Vasconcelos, C.; Medeiros, A.M.; Alves, A.C.; Bourbon, M.; Guerra, A. Abstract: Hypercholesterolemia results from an alteration, genetic or acquired, in lipoprotein metabolism. Evidence that hypercholesterolemia is associated with the atherosclerotic process from childhood justifies the screening of high-risk children and initiation of therapy at preschool ages. Fri, 10 May 2013 00:00:00 GMT http://hdl.handle.net/10400.18/1584 2013-05-10T00:00:00Z http://hdl.handle.net/10400.18/1583 Title: Sinapse: à procura de pistas para a etiologia das Perturbações do Espetro do Autismo Authors: Oliveira, Bárbara Fri, 19 Apr 2013 00:00:00 GMT http://hdl.handle.net/10400.18/1583 2013-04-19T00:00:00Z http://hdl.handle.net/10400.18/1582 Title: Investigação em Promoção da Saúde Authors: Miranda, Natércia Fri, 05 Apr 2013 00:00:00 GMT http://hdl.handle.net/10400.18/1582 2013-04-05T00:00:00Z http://hdl.handle.net/10400.18/1581 Title: Carcinogenic Ability of Schistosoma Haematobium Possibly through Oncogenic Mutation of KRAS Gene Authors: Botelho, Mónica C.; Veiga, Isabel; Oliveira, Paula A.; Lopes, Carlos; Teixeira, Manuel; Costa, José M Correia da; Machado, José C. Abstract: Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer, although why is not clear. Previously, we have used CD-1 mice to show that Schistosoma haematobium total antigen (Sh) has a carcinogenic ability. Sh intravesically instillation induced the development of several urothelial lesions, namely nodular hyperplasia and dysplasia (LGIUN—Low Grade Intra-Urothelial Neoplasia) after 40 weeks of treatment. These results suggested that Sh induce urothelium malignization. Bladder carcinoma frequently harbours gene mutations that constitutively activate the receptor tyrosine kinase-Ras pathway for this reason we studied activating mutations in KRAS gene. Twenty percent of the bladders with dysplasia presented a KRAS mutation in codon 12 of exon 2. We concluded from these results that the parasite extract of S. haematobium has carcinogenic ability possibly through oncogenic mutation of KRAS gene. Sun, 28 Apr 2013 00:00:00 GMT http://hdl.handle.net/10400.18/1581 2013-04-28T00:00:00Z